Pepperoni Spaghetti Bake Recipe

Pepperoni Spaghetti Bake

A unique spaghetti casserole -- Chef Boyardee Spaghetti and Meatballs layered with cheese on a biscuit base, topped with pepperoni and baked together for a flavorful 'pizza' style dish

Prep Time
Total Time
3.8 of 5 (186 ratings) Review This Recipe | See All Reviews


  • PAMŽ Original No-Stick Cooking Spray
  • 1-1/4 cups original baking mix
  • 1/2 cup reduced fat (2%) milk
  • 2 cans (14.5 oz each) Chef BoyardeeŽ Spaghetti & Meatballs
  • 3/4 cup shredded part-skim mozzarella cheese, divided
  • 1/3 cup sliced turkey pepperoni

Nutrition Information

Serving Size: 6 servings (1 cup each)
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  1. Preheat oven to 375°F. Spray 13x9-inch glass baking dish with cooking spray. Combine baking mix and milk in medium bowl; stir until soft dough forms.
  2. Drop dough by spoonfuls on bottom of baking dish (will not completely cover bottom). Spoon 1 can spaghetti and meatballs over dough and sprinkle with 1/2 cup cheese. Top with remaining can spaghetti and meatballs, remaining 1/4 cup cheese and pepperoni.
  3. Bake 20 to 25 minutes or until dough is done in centers and browned.

Cook's Tip

Add your favorite pizza toppings, if desired. Get the kids involved with preparation; they can prepare the dough, layer the ingredients and top the dish with pepperoni.
Nutrition Information close
Amount per Serving
Calories 298  
  % Daily Value*
Total fat 12 g 19%
Saturated fat 5 g 24%
Cholesterol 25 MG 8%
Sodium 852 MG 36%
Carbohydrate 34 g 11%
Dietary fiber 3 g 11%
Sugars 6 g
Protein 13 g
Vitamin A   5%
Vitamin C   0%
Calcium   17%
Iron   10%
* Percent Daily Values are based on a 2,000 calorie diet.
About our Nutrition Information
Ratings & Reviews
126 Reviews for Pepperoni Spaghetti Bake
more like chef-boy-ar-dont
May 08, 2013
Tryed your recipe was OK but done some changing up and was wonderful.Maybe you can try this to.Anyway no need for the biscuit base also use three cans of spaghetti and meatballs spray bottom of pan with Pam layer spaghetti and meatballs then add sliced pepperoni.On top put a layer of ricotto cheese then sprinkle with parmesman cheese on top and bake until hot throughout and cheese is bubble,serve with garden said and garlic roasted bread.Wonderful meal.
Apr 06, 2013
My family loved this meal! I had to add more cans than 2 to fill a 9x13 baking dish, but my family really enjoyed this meal. Other than that it will be a quick meal I will keep on hand for my lazy days :)
Feb 07, 2013
by reading the reviews and recipe I thought I would change the recipe a bit and use the chef boxed spaghettie and sauce (bought at walmart) only place I can find it. and then use bisquick or make my own biscuits Then go on from there for how long to cook. Good luck with the recipe.
Nov 24, 2012
So use GOOD spagetti leftovers instead of canned spagetti! Controls the sodium too!
Oct 30, 2012
Pepperoni spaghetti bake is absolutely horrible and not at all nutritious. Mushy spaghetti, mushy biscuit bottom! You don't mention the sodium content! 1 cup is too much to serve anyone!
Debbie d,
Oct 05, 2012
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